Homero debe salvar al mundo de una catástrofe que él mismo ha provocado. Todo comienza con Homero, su nueva mascota, un cerdo, y un silo lleno de excrementos que tiene una fuga, una combinación que desencadena un desastre distinto a todo lo que Springfield haya experimentado jamás. Mientras Marge está indignada por la monumental metedura de pata de su patán marido, una turba vengativa cae sobre el hogar de los Simpson...
Dan Castellaneta
Homer Simpson / Itchy / Barney / Abe Simpson / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen (voice)
Julie Kavner
Marge Simpson / Selma Bouvier / Patty Bouvier (voice)
Nancy Cartwright
Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone (voice)
Yeardley Smith
Lisa Simpson (voice)
Hank Azaria
Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy (voice)
Harry Shearer
Scratchy / Mr. Burns / Rev. Lovejoy / Ned Flanders / Lenny / Skull / President Arnold Schwarzenegger / Kent Brockman / Principal Skinner / Dr. Hibbert / Smithers / Toll Booth Man / Guard / Otto / Kang (voice)
Pamela Hayden
Milhouse Van Houten / Jimbo Jones / Rod Flanders (voice)
Tress MacNeille
Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice)
Albert Brooks
Russ Cargill (voice)
Karl Wiedergott
Man / EPA Driver (voice)
Marcia Wallace
Edna Krabappel (voice)
Russi Taylor
Martin Prince (voice)
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